[Effect of cascade plasma filtration on spectrum of subfractions of low density lipoproteins in blood plasma of patients with ischemic heart disease]. Kardiologiia 2014;54(4):10-5
Date
09/02/2014Pubmed ID
25177780DOI
10.18565/cardio.2014.4.10-15Scopus ID
2-s2.0-84900811229 (requires institutional sign-in at Scopus site)Abstract
We studied effect of cascade plasma filtration on subfractions of low density lipoproteins (LDL) in 16 patients with ischemic heart disease (IHD) and hyperlipidemias refractory to drug therapy. The procedure caused 37.6 ± 1.4%, 43.1 ± 2.5%, and 50.9 ± 1.4% lowering of total, low density lipoprotein cholesterol, and apolipoprotein B-100, respectively. The use of filters led to removal of larger less atherogenic LDL-1 and LDL-2 subfractions with relative accumulation of small dense LDL-3, LDL-4, and LDL-5 subfractions. Lowering of concentrations of all LDL subfractions was caused by specific LDL apheresis by immunosorbtion in 4 patients with IHD. Removal of small dense LDL was more effective than that of large less atherogenic LDL-1 and LDL-2 subfraction. Thus we found differences in spectrum of LDL removed by cascade plasma filtration and immunosorbtion. The use of filters was associated with less effective removal of most atherogenic small dense LDL than of large LDL particles what led to redistribution of concentrations of various LDL subfractions towards atherogenic profile of lipoproteins. These results could constitute a basis for revision of methods of conduct of cascade plasma filtration procedures in patients with IHD.
Author List
Utkina EA, Afanas'eva OI, Adamova IIu, Ezhov MV, Safarova MS, Artem'eva NV, Adzhiev RN, Pokrovskiĭ SNAuthor
Maya S. Safarova MD, PhD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultApolipoprotein B-100
Cholesterol, LDL
Drug Resistance
Female
Hemofiltration
Humans
Hyperlipidemias
Hypolipidemic Agents
Lipoproteins, LDL
Male
Middle Aged
Monitoring, Physiologic
Myocardial Ischemia
Treatment Outcome
