Faculty Collaboration Database

[Value of the spectral analysis of radiofrequency intravascular ultrasound data in the evaluation of nonsignificant coronary lesions in chronic CHD patients]. Kardiologiia 2011;51(10):4-8

Date

11/29/2011

Pubmed ID

22117674

Scopus ID

2-s2.0-84856071072 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

Plaque complication depends on its composition and phenotype rather than on the degree of stenosis. Plaque rupture predominantly occurs in areas with large lipid core rich in cholesterol and thin fibrous cap. Features of unstable atheromas are mostly described in patients with acute coronary syndromes (ACS). The aim of our study was to assess the plaque characterization and arterial remodeling process in non-significant stenoses of patients with chronic coronary heart disease (CHD) using intravascular ultrasound (IVUS) radiofrequency (RF) data. Methods. The study included 22 stable patients (68% men, mean age 54+/-6 years) with CHD and clinical indications for coronary angiography (CAG). Diameter stenosis of the target coronary artery for IVUS procedure had to be less than 60%. Thin-cap fibroatheroma (TCFA) was defined as plaque burden >40% and amount of NC >10% without detectable overlying fibrous cap segment. Results. Sample size calculations based on the IVUS evaluation showed 54 atheromas in 29 target arteries. Features of vulnerability determined as TCFA were detected in 14 (26%) lesions. Compared with stable lesions VPs were associated with a greater plaque burden (48.5+/-8.0 mm2 vs 55.8+/-9.3 mm2, p=0.03), larger quantity of necrotic core (37.1+/-9.1% vs 24.0+/-12.6%, p=0.0045) and calcium content (22.7+/-8.5% vs 5.6+/-5.2%, p<0.000l), and less fibrous component (34.8+/-7.0% vs 60.4+/-12.4%, p<0.0001), respectively. Significant correlation was obtained between positive remodeling (defined as remodeling index >1.05) and NC percent area (r=0.389. p=0.005). Conclusion. In chronic CHD patients about 25% of atherosclerotic lesions responsible for less than 60% stenosis could be classified as vulnerable plaques. These borderline lesions contain more necrotic and calcium components compared with stable plaques, and are associated with positive arterial remodeling.

Author List

Mitroshkin MG, Ezhov MV, Matchin IuG, Safarova MS, Soboleva DI, Dotsenko IuV

Author

Maya S. Safarova MD, PhD Assistant Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Cholesterol
Chronic Disease
Coronary Angiography
Coronary Vessels
Female
Humans
Male
Middle Aged
Myocardial Ischemia
Plaque, Atherosclerotic
Predictive Value of Tests
Reproducibility of Results
Rupture, Spontaneous
Severity of Illness Index
Ultrasonography, Interventional