Tonsillar p16-Positive Follicular Dendritic Cell Sarcoma Mimicking HPV-Related Oropharyngeal Squamous Cell Carcinoma: A Case Report and Review of Reported Cases. Head Neck Pathol 2021 Mar;15(1):267-274
Date
03/20/2020Pubmed ID
32189159Pubmed Central ID
PMC8010052DOI
10.1007/s12105-020-01152-0Scopus ID
2-s2.0-85082809601 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Follicular dendritic cell sarcoma (FDCS) is a rare entity which can share morphologic features with non-keratinizing squamous cell carcinoma. Recent reports suggest that up to half of FDCSs show immunohistochemical positivity for p16 (Zhang et al., in Hum Pathol 66:40-47, 2017), a stain that is conventionally used in the risk stratification of oropharyngeal squamous cell carcinoma (OPSCC). Herein, we report a case of p16-positive FDCS with clinical and histomorphologic overlap with human papilloma virus (HPV)-related OPSCC.
Author List
Hutchison B, Sadigh S, Ferry JA, Shattuck TM, Faquin WCAuthor
Bailey Hutchison MD Assistant Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultBiomarkers, Tumor
Cyclin-Dependent Kinase Inhibitor p16
Dendritic Cell Sarcoma, Follicular
Diagnosis, Differential
Humans
Male
Oropharyngeal Neoplasms
Tonsillar Neoplasms