Faculty Collaboration Database

Age alone is not a contraindication to kidney donation: Outcomes of donor nephrectomy in the elderly. Clin Transplant 2018 Aug;32(8):e13287

Date

06/21/2018

Pubmed ID

29923234

DOI

10.1111/ctr.13287

Scopus ID

2-s2.0-85052370116 (requires institutional sign-in at Scopus site)   14 Citations

Abstract

With increasing organ demand, living kidney donation from older donors (>60-years-old) has become more common. Between 1975 and 2014, 3752 donor nephrectomies (DN) were performed at University of Minnesota; 167 (4.5%) were >60-years-old Short- and long-term outcomes were compared between contemporaneous >60-years-old and <60-years-old donors. On univariate analysis, >60-years-old were more likely to have had prior abdominal surgery and hypertension; and less likely to smoke. Baseline estimated glomerular filtration rate (eGFR) was lower in >60-years-old (80 ± 16 vs 101 ± 26 mL/min/1.73 m² ; P < .001). Intraoperative and postoperative complications were similar, except a higher prevalence of <30 day ileus (3% vs 7%; P = .021) and longer postoperative length of stay (LOS) (4.2 vs 4.6 days; P = .005). On multivariate analysis, <30 day ileus and LOS continued to be significantly greater for >60-years-old After >20 years post-DN, systolic blood pressure was significantly higher among >60-years-old (142 vs 125 mm Hg; P < .001) and HTN was diagnosed earlier (9 vs 14 years). After donation, eGFR was significantly lower for >60-years-old but slope of eGFR and rates of end-stage renal disease (ESRD) were not significantly different >20 years post-DN. Thus, kidney donation among carefully selected >60-years-old poses minimal perioperative risks and no added risk of long-term ESRD.

Author List

Serrano OK, Yadav K, Bangdiwala A, Vock DM, Dunn TB, Finger EB, Pruett TL, Matas AJ, Kandaswamy R

Author

Ty Blink Dunn MD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Aged
Blood Pressure
Comorbidity
Contraindications
Female
Follow-Up Studies
Humans
Kidney Transplantation
Living Donors
Male
Middle Aged
Nephrectomy
Postoperative Complications
Prognosis
Retrospective Studies
Risk Assessment
Risk Factors
Tissue and Organ Harvesting