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Comparison of recipient outcomes following transplant from local versus imported pancreas donors. Am J Transplant 2012 Feb;12(2):447-57

Date

11/11/2011

Pubmed ID

22070451

DOI

10.1111/j.1600-6143.2011.03828.x

Scopus ID

2-s2.0-84856497172 (requires institutional sign-in at Scopus site)   20 Citations

Abstract

The shortage of deceased donor organs for solid organ transplantation continues to be an ongoing dilemma. One approach to increase the number of pancreas transplants is to share organs between procurement regions. To assess for the effects of organ importation, we reviewed the outcomes of 1014 patients undergoing deceased donor pancreas transplant at a single center. We performed univariate and multivariate analyses of the association of donor, recipient and surgical characteristics with patient outcomes. Organ importation had no effect on graft or recipient survival for recipients of solitary pancreas transplants. Similarly, there was no effect on technical failure rate, graft survival or long-term patient survival for simultaneous kidney-pancreas (SPK) recipients. In contrast, there was a significant and independent increased risk of death in the first year in SPK recipients of imported organs. SPK recipients had longer hospitalizations and increased hospital costs. This increased medical complexity may make these patients more susceptible to short-term complications resulting from the longer preservation times of import transplants. These findings support the continued use of organ sharing to reduce transplant wait times but highlight the importance of strategies to reduce organ preservation times.

Author List

Finger EB, Radosevich DM, Bland BJ, Dunn TB, Chinnakotla S, Sutherland DE, Pruett TL, Kandaswamy R

Author

Ty Blink Dunn MD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Female
Follow-Up Studies
Graft Survival
Humans
International Agencies
Male
Middle Aged
Pancreas Transplantation
Registries
Retrospective Studies
Tissue Donors
Tissue and Organ Procurement
Treatment Outcome
United States