Faculty Collaboration Database

Kidney transplant half-life (t[1/2]) after rapid discontinuation of prednisone. Transplantation 2009 Jan 15;87(1):100-2

Date

01/13/2009

Pubmed ID

19136898

Pubmed Central ID

PMC2766173

DOI

10.1097/TP.0b013e31818c25ab

Scopus ID

2-s2.0-58949089427 (requires institutional sign-in at Scopus site)   14 Citations

Abstract

Protocols incorporating rapid discontinuation of prednisone (RDP) after kidney transplantation have been associated with good short-term results. However, concern remains that RDP will be associated with decreased long-term graft survival rates. We compared kidney transplant half-life (t1/2) for recipients treated with antibody induction, calcineurin inhibitor, antimetabolite, and RDP versus historical controls treated with antibody induction, calcineurin inhibitor, antimetabolite, and maintenance prednisone. For both living and deceased donor recipients, we found no difference between groups. We also found no differences in rate of graft loss to acute rejection or to tubular atrophy and interstitial fibrosis. Our study suggests that long-term graft outcome is not decreased when using RDP protocols versus chronic maintenance prednisone.

Author List

Matas AJ, Gillingham K, Kandaswamy R, Dunn TB, Payne WD, Sutherland DE, Humar A

Author

Ty Blink Dunn MD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Female
Follow-Up Studies
Graft Rejection
Graft Survival
Humans
Kidney Transplantation
Male
Middle Aged
Prednisone
Time Factors