Faculty Collaboration Database

Transmission of anaplastic large cell lymphoma via organ donation after cardiac death. Am J Transplant 2008 Jan;8(1):238-44

Date

11/21/2007

Pubmed ID

18021286

DOI

10.1111/j.1600-6143.2007.02033.x

Scopus ID

2-s2.0-37549032140 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

Recently, donation after cardiac death (DCD) has been encouraged in order to expand the donor pool. We present a case of anaplastic T-cell lymphoma transmitted to four recipients of solid organ transplants from a DCD donor suspected of having bacterial meningitis. On brain biopsy, the donor was found to have anaplastic central nervous system T-cell lymphoma, and the recipient of the donor's pancreas, liver and kidneys were found to have involvement of T-cell lymphoma. The transplanted kidneys and pancreas were excised from the respective recipients, and the kidney and pancreas recipients responded well to chemotherapy. The liver recipient underwent three cycles of chemotherapy, but later died due to complications of severe tumor burden. We recommend transplanting organs from donors with suspected bacterial meningitis only after identification of the infectious organism. In cases of lymphoma transmission, excision of the graft may be the only chance at long-term survival.

Author List

Harbell JW, Dunn TB, Fauda M, John DG, Goldenberg AS, Teperman LW

Author

Ty Blink Dunn MD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Death
Female
Humans
Kidney Transplantation
Liver Transplantation
Lymphoma, Large-Cell, Anaplastic
Male
Meningitis, Bacterial
Middle Aged
Organ Transplantation
Pancreas Transplantation
Tissue Donors