Geriatric assessment in older adults with non-Hodgkin lymphoma: A Young International Society of Geriatric Oncology (YSIOG) review paper. J Geriatr Oncol 2022 Jun;13(5):572-581
Date
02/27/2022Pubmed ID
35216939Pubmed Central ID
PMC9232919DOI
10.1016/j.jgo.2022.02.005Scopus ID
2-s2.0-85125353864 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
Non-Hodgkin lymphoma (NHL) is a disease of older adults, with a median age at diagnosis of 67 years. Treatment in older adults with NHL is challenging. The aging process is associated with a decline in functional reserve that varies among individuals, and results in an increasing risk of treatment-related toxicity and mortality. Chronological age and performance status fail to capture the multidimensional and heterogeneous nature of the aging process. A geriatric assessment (GA) screens multiple geriatric domains and provides a more accurate assessment of functional reserve. Several abbreviated GA tools have been developed for use in oncology clinics and help identify patients at high risk for chemotherapy-related toxicity and mortality. In this review, we explore GA tools validated for use in patients with NHL. We discuss the evidence behind GA-guided treatment in NHL and present a suggested approach to assessing frailty in this patient population.
Author List
Akhtar OS, Huang LW, Tsang M, Torka P, Loh KP, Morrison VA, Cordoba RAuthor
Othman S. Akhtar MBBS Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedFrailty
Geriatric Assessment
Humans
Lymphoma, Non-Hodgkin
Neoplasms
