Acute lymphoblastic leukemia presenting as a breast lump: A report of two cases. J Cytol 2013 Jul;30(3):201-3
Date
10/17/2013Pubmed ID
24130415Pubmed Central ID
PMC3793360DOI
10.4103/0970-9371.117644Scopus ID
2-s2.0-84884544252 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Extra-medullary leukemic infiltration of the breast by acute lymphoblastic leukemia (ALL) is very rare. We report two cases of ALL presenting as breast masses and diagnosed on fine-needle aspiration (FNA). Our first patient, a post-partum 30-year-old female, developed bilateral breast lumps in her last trimester of pregnancy and complained of easy fatigability. Our second patient, a 14-year-old girl, presented with a right-breast lump of 1-week duration. She had received treatment for ALL 1 year back and had been in complete remission for the last 1 year. FNA of the breast nodules done in both the cases revealed diffuse infiltration by lymphoblasts. Subsequent hematological investigations confirmed bone marrow involvement by ALL in the first case and extra-medullary relapse in the second case. Fine-needle aspiration cytology (FNAC) is an easy and cost effective method for the early diagnosis of metastatic leukemic infiltration, avoiding unnecessary excisional biopsies in such cases.
