Faculty Collaboration Database

Retinoblastoma regression patterns following chemoreduction and adjuvant therapy in 557 tumors. Arch Ophthalmol 2009 Mar;127(3):282-90

Date

03/11/2009

Pubmed ID

19273791

DOI

10.1001/archophthalmol.2008.626

Scopus ID

2-s2.0-62449100167 (requires institutional sign-in at Scopus site)   54 Citations

Abstract

OBJECTIVE: To evaluate retinoblastoma regression patterns following chemoreduction and adjuvant therapy.

PARTICIPANTS: A total of 557 retinoblastomas.

METHODS: A retrospective medical record review following 6 cycles of chemoreduction and tumor consolidation (thermotherapy or cryotherapy). Regression patterns included type 0 (no remnant), type 1 (calcified remnant), type 2 (noncalcified remnant), type 3 (partially calcified remnant), and type 4 (flat scar).

MAIN OUTCOME MEASURES: Regression pattern.

RESULTS: Retinoblastoma regressions were type 0 (n = 10), type 1 (n = 75), type 2 (n = 28), type 3 (n = 127), and type 4 (n = 317). Tumors with an initial thickness of 3 mm or less regressed most often to type 4 (92%), those 3 to 8 mm regressed to type 3 (34%) or type 4 (40%), and those thicker than 8 mm regressed to type 1 (40%) or type 3 (49%). Factors predictive of type 1 regression included larger tumor base and closer foveolar proximity. Factors predictive of type 3 included older age, larger tumor base, macular location, closer foveolar proximity, and lack of consolidation. Factors predictive of type 4 included familial hereditary pattern, smaller tumor base, greater foveolar distance, and tumor consolidation.

CONCLUSIONS: Following chemoreduction, most small retinoblastomas result in a flat scar, intermediate tumors in a flat or partially calcified remnant, and large tumors in a more completely calcified remnant.

Author List

Shields CL, Palamar M, Sharma P, Ramasubramanian A, Leahey A, Meadows AT, Shields JA

Author

Aparna Ramasubramanian MD Associate Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Antineoplastic Combined Chemotherapy Protocols
Calcinosis
Carboplatin
Child, Preschool
Cryotherapy
Etoposide
Female
Humans
Hyperthermia, Induced
Infant
Male
Retinal Neoplasms
Retinoblastoma
Retrospective Studies
Vincristine