A general framework to develop a radiomic fingerprint for progression-free survival in cervical cancer. Brachytherapy 2023;22(6):728-735
Date
08/14/2023Pubmed ID
37574352DOI
10.1016/j.brachy.2023.06.004Scopus ID
2-s2.0-85168005570 (requires institutional sign-in at Scopus site)Abstract
PURPOSE: Treatment of locally advanced cervical cancer patients includes chemoradiation followed by brachytherapy. Our aim is to develop a delta radiomics (DRF) model from MRI-based brachytherapy treatment and assess its association with progression free survival (PFS).
MATERIALS AND METHODS: A retrospective analysis of FIGO stage IB- IV cervical cancer patients between 2012 and 2018 who were treated with definitive chemoradiation followed by MRI-based intracavitary brachytherapy was performed. Clinical factors together with 18 radiomic features extracted from different radiomics matrices were analyzed. The delta radiomic features (DRFs) were extracted from MRI on the first and last brachytherapy fractions. Support Vector Machine (SVM) models were fitted to combinations of 2-3 DRFs found significant after Spearman correlation and Wilcoxon rank sum test statistics. Additional models were tested that included clinical factors together with DRFs.
RESULTS: A total of 39 patients were included in the analysis with a median patient age of 52 years. Progression occurred in 20% of patients (8/39). The significant DRFs using two DRF feature combinations was a model using auto correlation (AC) and sum variance (SV). The best performing three feature model combined mean, AC & SV. Additionally, the inclusion of FIGO stages with the 2- and 3 DRF combination model(s) improved performance compared to models with only DRFs. However, all the clinical factor + DRF models were not significantly different from one another (all AUCs were 0.77).
CONCLUSIONS: Our study shows promising evidence that radiomics metrics are associated with progression free survival in cervical cancer.
Author List
Small C, Prior P, Nasief H, Zeitlin R, Saeed H, Paulson E, Morrow N, Rownd J, Erickson B, Bedi MAuthors
Manpreet Bedi MD, MS Professor in the Radiation Oncology department at Medical College of WisconsinBeth A. Erickson MD Professor in the Radiation Oncology department at Medical College of Wisconsin
Natalya V. Morrow PhD Assistant Professor in the Radiation Oncology department at Medical College of Wisconsin
Haidy G. Nasief PhD Instructor in the Radiation Oncology department at Medical College of Wisconsin
Eric Paulson PhD Chief, Professor in the Radiation Oncology department at Medical College of Wisconsin
Phillip Prior PhD Assistant Professor in the Radiation Oncology department at Medical College of Wisconsin
Jason Rownd MS Instructor in the Radiation Oncology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
BrachytherapyFemale
Humans
Magnetic Resonance Imaging
Middle Aged
Retrospective Studies
Uterine Cervical Neoplasms
