Hypereosinophilic Syndrome with Pulmonary Involvement in Ulcerative Colitis. JPGN Rep 2023 Aug;4(3):e320
Date
08/21/2023Pubmed ID
37600609Pubmed Central ID
PMC10435027DOI
10.1097/PG9.0000000000000320Abstract
Reactive eosinophilia is associated with inflammatory bowel disease and is more common in patients with ulcerative colitis (UC) compared with Crohn's disease. The prevalence rate of peripheral blood eosinophilia in patients with inflammatory bowel disease has been described to be as high as 30%-40% of patients in a pediatric study. The coexistence of hypereosinophilic syndrome (HES) and UC is uncommon. We present a 15-year-old boy with UC associated with HES who presented with chest pain and shortness of breath. Laboratory evaluation showed marked eosinophilia. Alternative causes of eosinophilia including eosinophilic leukemia, infections, or drug-induced eosinophilic pneumonia were ruled out. The patient was ultimately diagnosed with HES responsive to mepolizumab.
Author List
Bashir A, Cabrera JM, Suchi M, Pelz BJAuthors
Jose Mariano Cabrera MD Associate Professor in the Pediatrics department at Medical College of WisconsinBarry Joel Pelz MD Assistant Professor in the Pediatrics department at Medical College of Wisconsin
Mariko Suchi MD, PhD Associate Professor in the Pathology department at Medical College of Wisconsin
