Faculty Collaboration Database

Modulation of the synaptic drive to respiratory premotor and motor neurons. Respir Physiol 1997 Nov;110(2-3):161-76

Date

01/04/1998

Pubmed ID

9407609

DOI

10.1016/s0034-5687(97)00081-9

Scopus ID

2-s2.0-0030687877 (requires institutional sign-in at Scopus site)   80 Citations

Abstract

The characteristics of GABAergic inhibitory modulation of respiratory bulbospinal neuronal activity and short-term potentiation (STP) of phrenic motoneuronal activity were studied. Extracellular unit recording and picoejection techniques in anesthetized dogs showed that both the spontaneous rhythmic and reflexly induced discharge patterns of inspiratory (I) and expiratory (E) premotor neurons were proportionately amplified by the localized application of picomole amounts of bicuculline (Bic), a competitive GABAA antagonist. Intracellular recording and paired-pulse stimulation techniques in anesthetized rats demonstrated an STP of phrenic motor output that appears to be mediated by NMDA receptors and is associated with facilitation of EPSPs and prolonged depolarization of individual phrenic motoneurons. We speculate that both GABAergic gain modulation of premotor neuronal activity and NMDA-mediated STP of phrenic activity may be neural substrates which are involved with the optimization of respiratory and non-respiratory behaviors, via adaptive and/or differential control of breathing.

Author List

McCrimmon DR, Zuperku EJ, Hayashi F, Dogas Z, Hinrichsen CF, Stuth EA, Tonkovic-Capin M, Krolo M, Hopp FA

Authors

Eckehard A. Stuth MD Professor in the Anesthesiology department at Medical College of Wisconsin
Edward J. Zuperku PhD Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Action Potentials
Animals
Bicuculline
Dogs
Electric Stimulation
GABA Antagonists
Male
Motor Neurons
Neuronal Plasticity
Phrenic Nerve
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate
Respiratory Mechanics
Spinal Cord
Synapses
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
gamma-Aminobutyric Acid