Faculty Collaboration Database

Association between atopic dermatitis and autoimmune disorders in US adults and children: A cross-sectional study. J Am Acad Dermatol 2019 Feb;80(2):382-389

Date

10/06/2018

Pubmed ID

30287311

DOI

10.1016/j.jaad.2018.09.025

Scopus ID

2-s2.0-85058226782 (requires institutional sign-in at Scopus site)   60 Citations

Abstract

BACKGROUND: Little is known about the risk and predictors of autoimmune diseases in children and adults.

OBJECTIVE: To determine the prevalence, predictors, and excess costs of autoimmune disease in atopic dermatitis (AD) patients.

METHODS: Cross-sectional study of the 2002-2012 National Inpatient Sample, which includes a ∼20% sample of all US hospitalizations (n = 87,053,155 adults and children).

RESULTS: The prevalence of autoimmune disease was higher in adults with AD (7.9%, 95% confidence interval [95% CI] 7.3-8.5%) than without AD (5.7%, 95% CI 5.7%-5.8%) and higher in children with AD (2.0%, 95% CI 1.7%-2.3%) than without AD (1.0%, 95% CI 0.9%-1.1%). In multivariable logistic regression models controlling for sociodemographics, adult (adjusted odds ratio 1.45, 95% CI 1.32-1.58) and pediatric (adjusted odds ratio 2.08, 95% CI 1.73-2.50) AD were associated with any autoimmune disorder. In particular, AD was associated with 18 of 32 autoimmune disorders examined in adults and 13 of 24 examined in children, including disorders of the skin, endocrine, gastrointestinal, hematologic, and musculoskeletal systems. AD patients hospitalized with any autoimmune disorder had a higher cost of inpatient care, with $2.5-$50 million excess annual costs.

CONCLUSIONS: Adults and children with AD had increased cutaneous and extracutaneous autoimmune disorders, which were associated with a considerable cost burden.

Author List

Narla S, Silverberg JI

Author

Shanthi Narla MD Assistant Professor in the Dermatology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Age Distribution
Autoimmune Diseases
Child
Comorbidity
Cross-Sectional Studies
Dermatitis, Atopic
Female
Health Care Costs
Hospital Mortality
Hospitalization
Humans
Logistic Models
Male
Multivariate Analysis
Prevalence
Prognosis
Registries
Severity of Illness Index
Sex Distribution
Survival Rate
United States