Faculty Collaboration Database

Increasing insulin sensitivity lowers blood pressure in the fructose-fed rat. Am J Hypertens 1997 Sep;10(9 Pt 1):1020-6

Date

11/05/1997

Pubmed ID

9324108

DOI

10.1016/s0895-7061(97)00164-7

Scopus ID

2-s2.0-0030763565 (requires institutional sign-in at Scopus site)   55 Citations

Abstract

In the rat, simple carbohydrate feeding induces insulin resistance, and insulin resistance is associated with impaired endothelium dependent vasodilation. To determine if increasing insulin sensitivity corrects this defect of endothelial function, we evaluated the effects of an insulin-sensitizing agent, pioglitazone, on arterial pressure and in vitro vascular reactivity in three groups of Sprague Dawley rats: 1) control; 2) 60% fructose diet for 4 weeks; 3) 60% fructose diet plus pioglitazone (20 mg/kg daily, by oral gavage). Direct mean arterial pressure did not differ in Groups 1 (120 mm Hg +/- 2) and 2 (121 +/- 2) and was lower (P < .05) in Group 3 (112 +/- 2). In vitro uptake of tritiated glucose by adipocytes in response to insulin was reduced (P < .05) by fructose and increased (P < .01) by pioglitazone. In strips of thoracic aorta, norepinephrine-induced vasoconstriction and nitroprusside induced vasodilation did not differ among groups. However, in response to graded dose of acetylcholine, vasodilation was reduced (P < .05) by fructose; this was normalized by pioglitazone. In all groups, N(G)-nitro-L-arginine methyl ester (L-NAME) completely blocked acetylcholine-induced vasodilation. Thus, pioglitazone increased insulin sensitivity, lowered blood pressure, and normalized acetylcholine-induced vasodilation in insulin resistant, fructose-fed rats. Increasing insulin sensitivity may lower arterial pressure by augmenting endothelium dependent vasodilation.

Author List

Kotchen TA, Reddy S, Zhang HY

MESH terms used to index this publication - Major topics in bold

Acetylcholine
Adipocytes
Animals
Blood Pressure
Fructose
Glucose
Insulin
Insulin Resistance
Male
Norepinephrine
Rats
Rats, Sprague-Dawley
Thiazoles
Thiazolidinediones
Vasoconstrictor Agents
Vasodilation