Esophageal Dysfunction in Post-lung Transplant: An Enigma. Dysphagia 2023 Jun;38(3):731-743
Date
08/13/2022Pubmed ID
35960395DOI
10.1007/s00455-022-10508-3Scopus ID
2-s2.0-85135807197 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
The prevalence of lung transplants has increased over the years, albeit with a low survival rate amongst all solid organ transplants, including liver and heart transplantation. Microaspiration is one of the primary mechanisms that has been implicated in the pathogenesis of lung injury following lung transplants. Of late, esophageal dysfunction such as gastroesophageal reflux and esophageal hypercontractility is often noted post-lung transplant. However, reflux is associated with chronic allograft lung injury such as bronchiolitis obliterans syndrome, which is one of the predictors for long-term survival in this specialized population. Its role in acute lung injury post-lung transplant is still being explored. This review critically examines the salient points which provide the current understanding of the characteristics, pathophysiology, and implications of esophageal dysfunction following lung transplant.
Author List
Jadcherla AV, Litzenberg K, Balasubramanian GAuthor
Gokulakrishnan Balasubramanian MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Bronchiolitis ObliteransEsophageal Diseases
Gastroesophageal Reflux
Humans
Lung Injury
Lung Transplantation
