Faculty Collaboration Database

Cytochrome oxidase in Alzheimer's disease: biochemical, histochemical, and immunohistochemical analyses of the visual and other systems. Vision Res 1997 Dec;37(24):3593-608

Date

01/13/1998

Pubmed ID

9425533

DOI

10.1016/S0042-6989(96)00210-6

Scopus ID

2-s2.0-0030830677 (requires institutional sign-in at Scopus site)   119 Citations

Abstract

Defects in oxidative metabolism have been implicated in Alzheimer's disease (AD). The present study evaluated the level of cytochrome oxidase (C.O.), an indicator of neuronal oxidative capacity, in various brain regions of post-mortem AD and control patients. We found a statistically significant reduction in C.O. levels in all cortical areas examined, including the primary and secondary visual cortices. In addition, all layers of the dorsal lateral geniculate nucleus and sublaminae of the primary visual cortex in AD cases examined suffered a reduction in their relative C.O. activity and protein amount. Our results suggest a generalized suppression of oxidative metabolism throughout the cortex, as well as in a major subcortical visual center in AD. Such hypometabolism may form the basis for not only deficits in higher cortical functions, but also a variety of visual dysfunctions known to occur in AD.

Author List

Wong-Riley M, Antuono P, Ho KC, Egan R, Hevner R, Liebl W, Huang Z, Rachel R, Jones J

Author

Piero G. Antuono MD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Alzheimer Disease
Brain
Brain Chemistry
Densitometry
Electron Transport Complex IV
Geniculate Bodies
Histocytochemistry
Humans
Immunohistochemistry
Oxidation-Reduction
Plaque, Amyloid
Visual Cortex