Faculty Collaboration Database

Robust time-shifted spoke pulse design in the presence of large B0 variations with simultaneous reduction of through-plane dephasing, B1+ effects, and the specific absorption rate using parallel transmission. Magn Reson Med 2016 Aug;76(2):540-54

Date

10/08/2015

Pubmed ID

26444717

Pubmed Central ID

PMC4824674

DOI

10.1002/mrm.25902

Scopus ID

2-s2.0-84978405349 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

PURPOSE: To design parallel transmission spokes pulses with time-shifted profiles for joint mitigation of intensity variations due to B1+ effects, signal loss due to through-plane dephasing, and the specific absorption rate (SAR) at 7T.

METHODS: We derived a slice-averaged small tip angle (SA-STA) approximation of the magnetization signal at echo time that depends on the B1+ transmit profiles, the through-slice B0 gradient and the amplitude and time-shifts of the spoke waveforms. We minimize a magnitude least-squares objective based on this signal equation using a fast interior-point approach with analytical expressions of the Jacobian and Hessian.

RESULTS: Our algorithm runs in less than three minutes for the design of two-spoke pulses subject to hundreds of local SAR constraints. On a B0/B1+ head phantom, joint optimization of the channel-dependent time-shifts and spoke amplitudes allowed signal recovery in high-B0 regions at no increase of SAR. Although the method creates uniform magnetization profiles (ie, uniform intensity), the flip angle varies across the image, which makes it ill-suited to T1-weighted applications.

CONCLUSIONS: The SA-STA approach presented in this study is best suited to T2*-weighted applications with long echo times that require signal recovery around high B0 regions. Magn Reson Med 76:540-554, 2016. © 2015 Wiley Periodicals, Inc.

Author List

Guérin B, Stockmann JP, Baboli M, Torrado-Carvajal A, Stenger AV, Wald LL

Author

Mehran Baboli PhD Assistant Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Absorption, Radiation
Algorithms
Artifacts
Brain
Humans
Image Enhancement
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Phantoms, Imaging
Reproducibility of Results
Sensitivity and Specificity
Signal Processing, Computer-Assisted