Faculty Collaboration Database

Risk factors for febrile urinary tract infections in the first year after pediatric renal transplantation. Pediatr Transplant 2020 Feb;24(1):e13637

Date

12/28/2019

Pubmed ID

31880402

DOI

10.1111/petr.13637

Scopus ID

2-s2.0-85077392059 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

Urinary tract infection is the most common infectious complication following kidney transplant. Anatomic abnormalities, bladder dysfunction, a positive history of febrile urinary tract infection, and recipient age are reported risk factors. The aim of this study was to determine the risk factors for fUTI, which necessitated hospitalization in the first year after renal transplantation in our pediatric transplant population. A retrospective review of 195 pediatric patients who underwent kidney transplant between 2008 and 2017 from a single institution was performed. All patients admitted to the hospital with fUTI were marked for further analyses. The risk factors including age, gender, dialysis type, history of urologic disorders, and preoperative proteinuria for fUTI in the first year after kidney transplantation and graft survivals were investigated. Independent-sample t test and chi-square tests were used for univariate analysis. Exhaustive CHAID algorithm was used for multivariate analysis. The data of 115 male and 80 female patients were retracted. The mean ages of our cohort for males and females were 9.5 ± 5.1 and 10 ± 4.8 years, respectively. The age of the patients at transplant and their gender were found to be a statistically significant risk factors for developing fUTIs. Multivariate analysis showed that fUTI was common in female patients and a subgroup of male patients who had preoperative proteinuria, but no neurogenic bladder had higher risk compared with male patients without proteinuria. Patient surveillance and antibiotic prophylaxis algorithms can be developed to prevent febrile urinary tract infections seen after pediatric kidney transplantation in risky population.

Author List

Arpali E, Karatas C, Akyollu B, Akinci S, Gunaydin B, Sal O, Nayir A, Kocak B

Author

Emre Arpali MD, PhD Associate Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Child
Child, Preschool
Escherichia coli Infections
Female
Fever
Follow-Up Studies
Humans
Infant
Kidney Transplantation
Klebsiella Infections
Klebsiella pneumoniae
Male
Multivariate Analysis
Postoperative Complications
Retrospective Studies
Risk Factors
Urinary Tract Infections