Pancreas transplantation in older patients is safe, but patient selection is paramount. Transpl Int 2016 Jul;29(7):810-8
Date
02/10/2016Pubmed ID
26859581DOI
10.1111/tri.12754Scopus ID
2-s2.0-84976558607 (requires institutional sign-in at Scopus site) 38 CitationsAbstract
Pancreas transplant outcomes have progressively improved. Despite this, some centers have continued to employ historical age limits for pancreas transplant candidates. We sought to determine the importance of chronological age in determining patient and graft survival rates after pancreas transplantation. A single-center, retrospective study of adult, deceased donor simultaneous pancreas and kidney (SPK) and solitary pancreas transplants (SP, including pancreas transplant alone and pancreas after kidney transplants) in recipients ≥ 55 years (55 + ), occurring between July 1, 1999, and June 30, 2012, was performed. Seven-hundred and forty patients underwent pancreas transplantation, of which 28 patients were 55 + . Patient survival was comparable for younger and older pancreas transplant recipients. Both non-death-censored and death-censored pancreatic graft survival rates were similar in younger and in older patients. Patients aged 45-54 and those aged 55 + had more frequent cardiovascular events than younger pancreas transplant recipients. There was no difference in renal graft survival for SPK patients when compared with diabetic kidney transplant alone recipients aged 55 years and older. Older pancreas transplant recipients had acceptable long-term patient and graft survival rates, although complications may occur. Chronological age alone should not exclude a patient for pancreas transplant candidacy.
Author List
Scalea JR, Redfield RR 3rd, Arpali E, Leverson G, Sollinger HW, Kaufman DB, Odorico JSAuthor
Emre Arpali MD, PhD Associate Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Death
Diabetes Complications
Female
Graft Survival
Humans
Kidney Failure, Chronic
Kidney Transplantation
Male
Middle Aged
Pancreas Transplantation
Pancreatic Diseases
Patient Selection
Retrospective Studies
Time Factors
Tissue Donors
