Multifocality incidence and accompanying clinicopathological factors in renal cell carcinoma. Urol Int 2009;82(3):324-9
Date
05/15/2009Pubmed ID
19440022DOI
10.1159/000209366Scopus ID
2-s2.0-65949113388 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
INTRODUCTION: The incidence of multifocality and associated clinicopathological factors in renal cell carcinoma were evaluated.
MATERIALS AND METHODS: Clinicopathological characteristics were assessed for 122 renal cell carcinoma-pathological specimens from 121 patients. Microscopic and gross tumor pathology, incidence of multifocality as well as association between tumor grade, histological subtype, stage, size and vascular involvement were assessed.
RESULTS: Multifocal renal cell carcinoma was diagnosed in 16 of 122 specimens (13.1%). Satellite lesions for 15 of 16 specimens displaying multifocality had the same histological subtype as their primary tumor. The occult multifocality rate was 11.4%. Tumor grade and stage, but not size or volume, histological subtype, and vascular involvement were significantly related to multifocality.
CONCLUSIONS: Accurate staging of renal cell carcinoma appears to be essential in determining whether a patient should undergo nephron-sparing surgery or radical nephrectomy. Patients with high stage and grade should receive the highest attention after nephron-sparing surgery. Larger studies are needed to further elucidate the association between clinicopathological factors and multifocality.
Author List
Sargin SY, Ekmekcioglu O, Arpali E, Altinel M, Voyvoda BAuthor
Emre Arpali MD, PhD Associate Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Aged, 80 and over
Carcinoma, Renal Cell
Female
Humans
Incidence
Kidney Neoplasms
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Neoplasms, Multiple Primary
Nephrectomy
Patient Selection
Young Adult
