Progressive multifocal leukoencephalopathy in patients with chronic kidney disease. Neurol Sci 2024 Apr;45(4):1619-1624
Date
11/11/2023Pubmed ID
37950135DOI
10.1007/s10072-023-07182-0Scopus ID
2-s2.0-85176588688 (requires institutional sign-in at Scopus site)Abstract
Progressive multifocal leukoencephalopathy (PML) is an opportunistic central nervous system infection caused by the human polyomavirus 2, leading to demyelination from oligodendrocyte death and rapid neurologic decline. Most commonly, PML affects patients in immunocompromised states. However, rare reports of PML in an immunocompetent host exist. Here, we report two cases of PML in older individuals with chronic kidney disease (CKD). CKD can ultimately lead to immune system dysfunction and place patients in a relatively immunosuppressed state. Testing for JC virus should remain a consideration for rapid, unexplained neurologic decline even without known immunocompromised status in the appropriate clinical setting.
Author List
Meylor J, Artunduaga DC, Mendoza M, Hooshmand SI, Obeidat AZAuthors
Sam I. Hooshmand DO Assistant Professor in the Neurology department at Medical College of WisconsinAhmed Zayed Obeidat MD, PhD Associate Professor in the Neurology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AgedHumans
Immunocompromised Host
JC Virus
Leukoencephalopathy, Progressive Multifocal
Renal Insufficiency, Chronic
