Modulating Cytokine Production via Select Packaging and Secretion From Extracellular Vesicles. Front Immunol 2020;11:1040
Date
06/18/2020Pubmed ID
32547552Pubmed Central ID
PMC7272603DOI
10.3389/fimmu.2020.01040Scopus ID
2-s2.0-85086514254 (requires institutional sign-in at Scopus site) 43 CitationsAbstract
Cytokines are soluble factors that play vital roles in systemic function due to their ability to initiate and mediate cell-to-cell communication. Another important mechanism of intercellular communication that has gained significant attention in the past 10 years is the release of extracellular vesicles (EVs). EVs are released by all cells during normal physiology, in states of resting and activation, as well as during disease. Accumulating evidence indicates that cytokines may be packaged into EVs, and the packaging of cytokines into EVs, along with their ultimate secretion, may also be regulated by cytokines. Importantly, the repertoire of biomolecules packaged into EVs is shaped by the biological state of the cell (resting vs. activated and healthy vs. disease) and the EV biogenesis pathway involved, thus providing mechanisms by which EV packaging and secretion may be modulated. Given the critical role of cytokines in driving acute and chronic inflammatory and autoimmune diseases, as well as their role in establishing the tumor immune microenvironment, in this review, we will focus on these disease settings and summarize recent progress and mechanisms by which cytokines may be packaged within and modulated by EVs, as a therapeutic option for regulating innate and adaptive immunity.
Author List
Barnes BJ, Somerville CCAuthor
Carter C. Somerville PhD Research Scientist I in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adaptive ImmunityAnimals
Autoimmune Diseases
Cytokines
Extracellular Vesicles
Humans
Immunity, Innate
Immunomodulation
Immunotherapy
Inflammation
Neoplasms
Tumor Microenvironment
