Consistency of the continuous flow pressure gradient despite aortic arch anomalies co-existing with coarctation. medRxiv 2023 Oct 30
Date
11/14/2023Pubmed ID
37961134Pubmed Central ID
PMC10635219DOI
10.1101/2023.10.30.23297763Abstract
AIMS: Severity assessment for coarctation of the aorta (CoA) is challenging due to concomitant morphological anomalies (complex CoA) and inaccurate Doppler-based indices. Promising diagnostic performance has been reported for the continuous flow pressure gradient (CFPG), but it has not been studied in complex CoA. Our objective was to characterize the effect of complex CoA and associated hemodynamics on CFPG in a clinical cohort.
METHODS AND RESULTS: Retrospective analysis identified discrete juxtaductal (n=25) and complex CoA (n=43; transverse arch and/or isthmus hypoplasia) patients with arm-leg systolic blood pressure gradients (BPG) within 24 hours of echocardiography for comparison to BPG by conventional Doppler indices (simplified Bernoulli equation and modified forms correcting for proximal kinetic energy and/or recovered pressure). Results were interpreted using the current CoA guideline (BPG ≥20 mmHg) to compare diagnostic performance indicators including receiver operating characteristic curves, sensitivity, specificity, and diagnostic accuracy, among others. Echocardiography Z-scored aortic diameters were applied with computational stimulations from a preclinical CoA model to understand aspects of the CFPG driving performance differences.Diagnostic performance was substantially reduced from discrete to complex CoA for conventional Doppler indices calculated from patient data, and by hypoplasia and/or long segment stenosis in simulations. In contrast, diagnostic indicators for the CFPG only modestly dropped for complex vs discrete CoA. Simulations revealed differences in performance due to inclusion of the Doppler velocity index and diastolic pressure half-time in the CFPG calculation.
CONCLUSION: CFPG is less affected by aortic arch anomalies co-existing with CoA when compared to conventional Doppler indices.
Author List
Ghorbannia A, Spearman AD, Sawalhi S, Woods RK, Maadooliat M, LaDisa JF JrAuthors
John F. LaDisa PhD Professor in the Pediatrics department at Medical College of WisconsinAndrew Spearman MD Assistant Professor in the Pediatrics department at Medical College of Wisconsin
Ronald K. Woods MD Professor in the Surgery department at Medical College of Wisconsin
