Improved survival with co-trimoxazole prophylaxis among people living with HIV/AIDS who initiated antiretroviral treatment in Henan Province, China. Curr HIV Res 2014;12(5):359-65
Date
11/27/2014Pubmed ID
25426939Pubmed Central ID
PMC4719052DOI
10.2174/1570162x1205141121102155Scopus ID
2-s2.0-84919761402 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
OBJECTIVES: This study aims to evaluate the effect of co-trimoxazole (CTX) prophylaxis on mortality reduction among HIV-infected patients receiving antiretroviral therapy (ART) in Henan Province, China.
DESIGN: We conducted a retrospective study.
METHODS: All individuals aged 15 years and older who initiated ART between 2008 and 2010 in Henan Province with completed CTX prophylaxis treatment information were included. The effect of CTX prophylaxis was estimated using Kaplan-Meier survival analysis and multivariate Cox proportional hazard modeling for mortality at 3-months and 12-months after ART initiation.
RESULTS: Overall mortality among patients receiving both ART and CTX was nearly double at 3-months after ART initiation compared with that at 12-months (12.4 per 100 PY vs 6.3 per 100 PY, p < 0.01). After adjusting for gender, age, TB history, year of ART initiation and CD4 count at ART initiation, CTX was associated with a significant reduction in 12-month mortality (adjusted hazard ratio (AHR) = 0.65, 95% confidence interval (CI): 0.44-0.95; p = 0.027) compared with persons not receiving CTX. The protective effect was more pronounced in the first 3 months after ART initiation (AHR = 0.53, 95% CI: 0.32-0.89; p = 0.017).
CONCLUSION: CTX prophylaxis together with ART reduced mortality of adult HIV patients during the first 12 months of ART in Henan Province, China. The effect was highest in the first 3 months of ART. CTX should be prescribed to all HIV-infected adults who initiate ART.
Author List
Zhu Q, Wang L, Lin W, Bulterys M, Yang W, Sun D, Cui Z, Kaplan J, Kleinman N, Wei X, Chung J, Wang ZAuthor
Jessica S. Chung MD Adjunct Instructor in the Obstetrics and Gynecology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AIDS-Related Opportunistic InfectionsAdolescent
Adult
Anti-Infective Agents
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
China
Female
HIV Infections
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Retrospective Studies
Trimethoprim, Sulfamethoxazole Drug Combination
Young Adult
