Faculty Collaboration Database

Histone Modifications and Their Contributions to Hypertension. Hypertension 2024 Feb;81(2):229-239

Date

11/30/2023

Pubmed ID

38031837

DOI

10.1161/HYPERTENSIONAHA.123.21755

Scopus ID

2-s2.0-85182776843 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

Essential hypertension, a multifaceted disorder, is a worldwide health problem. A complex network of genetic, epigenetic, physiological, and environmental components regulates blood pressure (BP), and any dysregulation of this network may result in hypertension. Growing evidence suggests a role for epigenetic factors in BP regulation. Any alterations in the expression or functions of these epigenetic regulators may dysregulate various determinants of BP, thereby promoting the development of hypertension. Histone posttranslational modifications are critical epigenetic regulators that have been implicated in hypertension. Several studies have demonstrated a clear association between the increased expression of some histone-modifying enzymes, especially HDACs (histone deacetylases), and hypertension. In addition, treatment with HDAC inhibitors lowers BP in hypertensive animal models, providing an excellent opportunity to design new drugs to treat hypertension. In this review, we discuss the potential contribution of different histone modifications to the regulation of BP.

Author List

Ray A, Stelloh C, Liu Y, Meyer A, Geurts AM, Cowley AW Jr, Greene AS, Liang M, Rao S

Authors

Aron Geurts PhD Professor in the Physiology department at Medical College of Wisconsin
Sridhar Rao MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Epigenesis, Genetic
Essential Hypertension
Histone Code
Histones
Hypertension
Protein Processing, Post-Translational