Ibuprofen use to reduce the incidence and severity of bronchopulmonary dysplasia: a pilot study. J Perinatol 2000;20(1):13-6
Date
02/29/2000Pubmed ID
10693094DOI
10.1038/sj.jp.7200296Scopus ID
2-s2.0-0033627697 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
OBJECTIVE: To assess the safety and efficacy of ibuprofen in reducing the incidence and severity of bronchopulmonary dysplasia (BPD) in preterm infants.
METHODS: A total of 18 premature infants between 23 and 28 weeks' gestation were studied. Ibuprofen (10 mg/kg of loading dose followed by 5 mg/kg every 12 hours) was administered intravenously or orally to nine infants on respiratory support at > or = 7 days of age and was continued until 28 days of life or until the infants were spontaneously breathing room air, whichever occurred earlier. Ibuprofen levels in plasma were measured in five of these infants. The outcome variables (BPD, ventilatory parameters, and complications) in the study group were compared with those in nine matched controls treated conventionally.
RESULTS: The incidence of BPD at 36 weeks postconceptional age was similar in both groups (eight of nine in each group). The percentage of oxygen requirement, the ventilatory efficiency index, and steroid use were also similar in both groups. One infant in the study group, who was also receiving steroids and aminophylline, developed gastrointestinal hemorrhage. Reversible renal failure in one infant and necrotizing enterocolitis in another infant were seen at 4 and 21 days, respectively, after the last dose of ibuprofen. There was no difference in the incidence of intraventricular hemorrhage between the two groups. Plasma levels of ibuprofen at 3 hours after the first dose ranged from 10.3 to 36 mg/liter. Study infants tolerated the feeds better and achieved the full enteral goal earlier than controls (p = 0.04).
CONCLUSION: Although a trend toward less ventilator and hospital days in the ibuprofen group was observed in this pilot study, the differences were not statistically significant. The incidence of BPD was similar in both groups. In the study group, two infants developed gastrointestinal complications and a third infant experienced reversible renal failure. The plasma ibuprofen levels were low. Further studies are needed to assess the use of ibuprofen for the prevention and/or treatment of BPD in preterm infants.
Author List
Raju NV, Bharadwaj RA, Thomas R, Konduri GGAuthor
Girija Ganesh Konduri MD Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Administration, OralAnti-Inflammatory Agents, Non-Steroidal
Bronchopulmonary Dysplasia
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Ibuprofen
Incidence
Infant, Newborn
Infant, Premature, Diseases
Injections, Intravenous
Male
Pilot Projects
Severity of Illness Index
Statistics, Nonparametric
Treatment Outcome
