Complex karyotype predicts for inferior outcomes following reduced-intensity conditioning allogeneic transplant for chronic lymphocytic leukaemia. Br J Haematol 2012 Oct;159(1):82-7
Date
07/27/2012Pubmed ID
22831395Pubmed Central ID
PMC3719859DOI
10.1111/j.1365-2141.2012.09239.xScopus ID
2-s2.0-84866334906 (requires institutional sign-in at Scopus site) 49 CitationsAbstract
Complex karyotype (CK) on metaphase cytogenetics discriminates poor outcome in chronic lymphocytic leukaemia (CLL) patients undergoing salvage treatment; we hypothesized that it might provide prognostic information for patients undergoing allogeneic stem cell transplant. Fifty-one CLL patients were analysed following transplant; 18-month overall survival (OS), event-free survival (EFS) and cumulative incidence of progression estimates were 35%, 14% and 63%, respectively, in patients with CK (n = 19) versus 83%, 68% and 29% in patients without (n = 32) (P ≤ 0·0001, P ≤ 0·0001, and P = 0·02). In patients with high-risk interphase cytogenetics, CK remained predictive of worse OS (P = 0·02) and EFS (P = 0·009). These findings support further evaluation of metaphase karyotype in transplant risk assessment.
Author List
Jaglowski SM, Ruppert AS, Heerema NA, Bingman A, Flynn JM, Grever MR, Jones JA, Elder P, Devine SM, Byrd JC, Andritsos LAAuthor
Samantha M. Jaglowski MD, MPH Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Cytogenetics
Disease-Free Survival
Female
Humans
In Situ Hybridization, Fluorescence
Karyotype
Leukemia, Lymphocytic, Chronic, B-Cell
Male
Middle Aged
Prognosis
Stem Cell Transplantation
Survival Analysis
Transplantation Conditioning
Transplantation, Homologous
Treatment Outcome
