Common Variable Immunodeficiency. Med Clin North Am 2024 Jan;108(1):107-121
Date
11/12/2023Pubmed ID
37951645DOI
10.1016/j.mcna.2023.06.012Scopus ID
2-s2.0-85165659522 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Common variable immunodeficiency (CVID) is the most common primary immune deficiency characterized by impaired production of specific immunoglobulin. The clinical manifestations are heterogeneous including acquisition of recurrent bacterial infections after a period of wellness, lymphoproliferation, autoimmunity, pulmonary disease, liver disease, enteropathy, granulomas, and an increased risk of malignancy. The etiology of CVID is largely unknown, with a considerable number of patients having an underlying genetic defect causing immune dysregulation. The antibody deficiency found in CVID is treated with lifelong immunoglobulin therapy, which is preventative of the majority of infections when given regularly.
Author List
Remiker A, Bolling K, Verbsky JAuthor
James Verbsky MD, PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AutoimmunityCommon Variable Immunodeficiency
Humans
