Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge. Pediatr Allergy Immunol 2003 Oct;14(5):409-11
Date
12/04/2003Pubmed ID
14641613DOI
10.1034/j.1399-3038.2003.00073.xScopus ID
2-s2.0-0242416147 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
We report the management of a 15-year-old boy with an anaphylactic or anaphylactoid response to his first dose of methotrexate during induction therapy for acute lymphoblastic leukemia (ALL). Because weekly methotrexate therapy is an important component of continuation chemotherapy for pediatric ALL, a stepwise graded challenge was employed to achieve drug tolerance.
Author List
MacGinnitie AJ, Walensky LD, Turvey SE, Orange JS, Bonilla FA, Silverman LB, Oettgen HAuthor
Andrew J. MacGinnitie MD, PhD Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAnaphylaxis
Anti-Allergic Agents
Antimetabolites, Antineoplastic
Antipruritics
Diphenhydramine
Dose-Response Relationship, Drug
Drug Eruptions
Drug Therapy, Combination
Histamine H2 Antagonists
Humans
Male
Methotrexate
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pruritus
Ranitidine
Skin Tests
Urticaria