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Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge. Pediatr Allergy Immunol 2003 Oct;14(5):409-11

Date

12/04/2003

Pubmed ID

14641613

DOI

10.1034/j.1399-3038.2003.00073.x

Scopus ID

2-s2.0-0242416147 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

We report the management of a 15-year-old boy with an anaphylactic or anaphylactoid response to his first dose of methotrexate during induction therapy for acute lymphoblastic leukemia (ALL). Because weekly methotrexate therapy is an important component of continuation chemotherapy for pediatric ALL, a stepwise graded challenge was employed to achieve drug tolerance.

Author List

MacGinnitie AJ, Walensky LD, Turvey SE, Orange JS, Bonilla FA, Silverman LB, Oettgen H

Author

Andrew J. MacGinnitie MD, PhD Chief, Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Anaphylaxis
Anti-Allergic Agents
Antimetabolites, Antineoplastic
Antipruritics
Diphenhydramine
Dose-Response Relationship, Drug
Drug Eruptions
Drug Therapy, Combination
Histamine H2 Antagonists
Humans
Male
Methotrexate
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pruritus
Ranitidine
Skin Tests
Urticaria