Changes in Therapy Are Not Associated With Increased Remission in Patients With Crohn's Disease of the Pouch. Am J Gastroenterol 2024 Mar 01;119(3):584-587
Date
11/17/2023Pubmed ID
37975591Pubmed Central ID
PMC11273367DOI
10.14309/ajg.0000000000002599Scopus ID
2-s2.0-85187115149 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
INTRODUCTION: There is a paucity of data on the real-world effectiveness of therapies in patients with Crohn's disease of the pouch.
METHODS: This was a prospective multicenter study evaluating the primary outcome of remission at 12 months of therapy for Crohn's disease of the pouch.
RESULTS: One hundred thirty-four patients were enrolled. Among the 77 patients with symptoms at baseline, 35 (46.7%) achieved remission at 12 months. Of them, 12 (34.3%) changed therapy. There was no significant association between therapy patterns and remission status.
DISCUSSION: Approximately 50% with symptoms at enrollment achieved clinical remission at 12 months, most of whom did so without a change in therapy.
Author List
Kayal M, Deepak P, Beniwal-Patel P, Raffals L, Dubinsky M, Chang S, Higgins PDR, Jiang Y, Cross RK, Long MD, Herfarth HH, Barnes ELAuthor
Poonam Beniwal-Patel MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultColonic Pouches
Crohn Disease
Female
Humans
Immunosuppressive Agents
Infliximab
Male
Middle Aged
Pouchitis
Proctocolectomy, Restorative
Prospective Studies
Remission Induction
Treatment Outcome
