Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantation. Lancet 1991 Jul 20;338(8760):147-9

Date

07/20/1991

Pubmed ID

1677066

DOI

10.1016/0140-6736(91)90137-e

Scopus ID

2-s2.0-0025856771 (requires institutional sign-in at Scopus site)   270 Citations

Abstract

Severe interstitial pneumonitis in 2 marrow-transplant recipients was associated with human herpesvirus-6 (HHV-6) infection. The virus was repeatedly detected in respiratory specimens from 1 patient, and HHV-6-infected cells were shown in lung tissue from both patients by immunohistochemical staining. The infected cells were primarily intra-alveolar macrophages, although infected lymphocytes were seen. HHV-6 should be considered as a cause of unexplained lung disease in marrow-transplant recipients and other immunocompromised patients.

Author List

Carrigan DR, Drobyski WR, Russler SK, Tapper MA, Knox KK, Ash RC

Author

William R. Drobyski MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Bone Marrow Transplantation
Bronchoalveolar Lavage Fluid
Female
Herpesviridae Infections
Herpesvirus 6, Human
Humans
Immune Tolerance
Immunohistochemistry
Male
Prospective Studies
Pulmonary Fibrosis