Faculty Collaboration Database

Effects of calcium channel inhibitors on ethanol effects and pharmacokinetics in healthy volunteers. Alcohol 1993;10(6):505-9

Date

11/01/1993

Pubmed ID

8123209

DOI

10.1016/0741-8329(93)90074-x

Scopus ID

2-s2.0-0027763246 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

Previous studies have shown that calcium channel antagonists alter the effects of alcohol in animals and humans. We selected a phenylalkylamine, verapamil, and a dihydropyridine, nimodipine, to determine whether these drugs would affect the subjective or psychomotor effects of ethanol in humans. Subjects ingested verapamil (80 mg, PO), nimodipine (30 and 60 mg, PO), or placebo 60 min before drinking an alcohol (0.7 g/kg) or placebo beverage. Subjects' mood, psychomotor performance, physiological status, and blood alcohol levels were assessed up to 3 h after beverage ingestion. Alcohol increased "drunk" ratings and impaired psychomotor performance (p < 0.05). Blood alcohol levels were decreased by nimodipine pretreatment, but not by verapamil pretreatment. Subjective and psychomotor effects of alcohol were not altered as a function of nimodipine or verapamil pretreatment. Nimodipine, verapamil, and alcohol, either alone or in combination, had no effect on blood pressure or heart rate.

Author List

Zacny JP, Yajnik S

Author

Santosh Yajnik MD Associate Professor in the Radiation Oncology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Alcohol Drinking
Cognition
Double-Blind Method
Ethanol
Humans
Male
Nifedipine
Placebos
Psychomotor Performance
Reference Values
Verapamil