Targeting Cysteine Oxidation in Thrombotic Disorders. Antioxidants (Basel) 2024 Jan 09;13(1)
Date
01/22/2024Pubmed ID
38247507Pubmed Central ID
PMC10812781DOI
10.3390/antiox13010083Scopus ID
2-s2.0-85183412516 (requires institutional sign-in at Scopus site)Abstract
Oxidative stress increases the risk for clinically significant thrombotic events, yet the mechanisms by which oxidants become prothrombotic are unclear. In this review, we provide an overview of cysteine reactivity and oxidation. We then highlight recent findings on cysteine oxidation events in oxidative stress-related thrombosis. Special emphasis is on the signaling pathway induced by a platelet membrane protein, CD36, in dyslipidemia, and by protein disulfide isomerase (PDI), a member of the thiol oxidoreductase family of proteins. Antioxidative and chemical biology approaches to target cysteine are discussed. Lastly, the knowledge gaps in the field are highlighted as they relate to understanding how oxidative cysteine modification might be targeted to limit thrombosis.
