Efficient estimation for left-truncated competing risks regression for case-cohort studies. Biometrics 2024 Jan 29;80(1)
Date
01/29/2024Pubmed ID
38281769Pubmed Central ID
PMC10826882DOI
10.1093/biomtc/ujad008Scopus ID
2-s2.0-85184145902 (requires institutional sign-in at Scopus site)Abstract
The case-cohort study design provides a cost-effective study design for a large cohort study with competing risk outcomes. The proportional subdistribution hazards model is widely used to estimate direct covariate effects on the cumulative incidence function for competing risk data. In biomedical studies, left truncation often occurs and brings extra challenges to the analysis. Existing inverse probability weighting methods for case-cohort studies with competing risk data not only have not addressed left truncation, but also are inefficient in regression parameter estimation for fully observed covariates. We propose an augmented inverse probability-weighted estimating equation for left-truncated competing risk data to address these limitations of the current literature. We further propose a more efficient estimator when extra information from the other causes is available. The proposed estimators are consistent and asymptotically normally distributed. Simulation studies show that the proposed estimator is unbiased and leads to estimation efficiency gain in the regression parameter estimation. We analyze the Atherosclerosis Risk in Communities study data using the proposed methods.
Author List
Fang X, Ahn KW, Cai J, Kim SAuthors
Kwang Woo Ahn PhD Professor in the Institute for Health and Equity department at Medical College of WisconsinSoyoung Kim PhD Associate Professor in the Institute for Health and Equity department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Cohort StudiesComputer Simulation
Humans
Incidence
Probability
Proportional Hazards Models
