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Precursor B-lymphoblastic transformation of grade I follicle center lymphoma. Am J Clin Pathol 2000 Mar;113(3):411-8

Date

03/08/2000

Pubmed ID

10705823

DOI

10.1309/Y2YD-UNA2-C95R-AVM3

Scopus ID

2-s2.0-0034006151   35 Citations

Abstract

Part of the natural history of follicle center lymphoma (FCL) is transformation to a more aggressive neoplasm, almost always a diffuse large B-cell lymphoma. We describe a rare example of a precursor B-lymphoblastic transformation of grade I FCL occurring in a 45-year-old woman 12 years after initial presentation and 3 years after successful treatment for a diffuse large cell transformation. The lymphoblastic lymphoma shared the same immunoglobulin heavy chain gene rearrangement as the FCL as assessed by polymerase chain reaction amplification and direct sequencing, as well as identical kappa light chain gene rearrangements by Southern blot analysis. The immunoglobulin heavy chain variable gene sequences of both tumors showed numerous identical base substitutions compared with germline sequences and 3 additional mutations in the lymphoblastic lymphoma not present in the low-grade FCL. These results indicate origin of the lymphoblastic process from the mature follicle center B-cell clone, rather than divergent origin of the 2 tumors from a common immature B-cell precursor.

Author List

Kroft SH, Domiati-Saad R, Finn WG, Dawson DB, Schnitzer B, Singleton TP, Ross CW

Author

Steven Howard Kroft MD Chair, Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Base Sequence
Blotting, Southern
Cell Transformation, Neoplastic
DNA, Neoplasm
Female
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Genes, bcl-2
Humans
Immunoenzyme Techniques
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Lymphoma, B-Cell
Lymphoma, Follicular
Molecular Sequence Data
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma