Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans. Cell 2013 Oct 10;155(2):308-20
Date
10/15/2013Pubmed ID
24120132Pubmed Central ID
PMC3881433DOI
10.1016/j.cell.2013.08.058Scopus ID
2-s2.0-84885673994 (requires institutional sign-in at Scopus site) 113 CitationsAbstract
Sensory dendrites depend on cues from their environment to pattern their growth and direct them toward their correct target tissues. Yet, little is known about dendrite-substrate interactions during dendrite morphogenesis. Here, we describe MNR-1/menorin, which is part of the conserved Fam151 family of proteins and is expressed in the skin to control the elaboration of "menorah"-like dendrites of mechanosensory neurons in Caenorhabditis elegans. We provide biochemical and genetic evidence that MNR-1 acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites. Our data describe an unknown pathway that provides spatial information from the skin substrate to pattern sensory dendrite development nonautonomously.
Author List
Salzberg Y, Díaz-Balzac CA, Ramirez-Suarez NJ, Attreed M, Tecle E, Desbois M, Kaprielian Z, Bülow HEAuthor
Eillen Tecle PhD Assistant Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Amino Acid SequenceAnimals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cloning, Molecular
Dendrites
Gene Knockdown Techniques
Membrane Proteins
Molecular Sequence Data
Neurons
Sequence Alignment
