A stochastic model for cancer stem cell origin in metastatic colon cancer. Cancer Res 2008 Sep 01;68(17):6932-41
Date
09/02/2008Pubmed ID
18757407Pubmed Central ID
PMC2562348DOI
10.1158/0008-5472.CAN-07-5779Scopus ID
2-s2.0-52049117849 (requires institutional sign-in at Scopus site) 140 CitationsAbstract
Human cancers have been found to include transformed stem cells that may drive cancer progression to metastasis. Here, we report that metastatic colon cancer contains clonally derived tumor cells with all of the critical properties expected of stem cells, including self-renewal and the ability to differentiate into mature colon cells. Additionally, when injected into mice, these cells initiated tumors that closely resemble human cancer. Karyotype analyses of parental and clonally derived tumor cells expressed many consistent (clonal) along with unique chromosomal aberrations, suggesting the presence of chromosomal instability in the cancer stem cells. Thus, this new model for cancer origin and metastatic progression includes features of both the hierarchical model for cancerous stem cells and the stochastic model, driven by the observation of chromosomal instability.
Author List
Odoux C, Fohrer H, Hoppo T, Guzik L, Stolz DB, Lewis DW, Gollin SM, Gamblin TC, Geller DA, Lagasse EAuthor
Thomas Clark Gamblin MD Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Animals
Colorectal Neoplasms
Female
Humans
Male
Mice
Mice, Knockout
Microscopy, Electron, Transmission
Middle Aged
Neoplasm Metastasis
Neoplastic Stem Cells
Stochastic Processes
