Faculty Collaboration Database

Microvascular flow ultrasound imaging for retinoblastoma. J AAPOS 2024 Feb;28(1):103801

Date

01/12/2024

Pubmed ID

38211831

DOI

10.1016/j.jaapos.2023.10.003

Scopus ID

2-s2.0-85184232966 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

PURPOSE: To present the results of a pilot study of microvascular flow imaging (MFI) in characterizing tumor vasculature of retinoblastoma.

METHODS: The medical records of consecutive patients with retinoblastoma presenting at our institution between July 2019 and June 2022 that were imaged using MFI were reviewed retroactively. Each patient underwent diagnostic evaluation according to standard of care by examination under anesthesia with fluorescein angiography and ocular ultrasound imaging, including color Doppler and MFI.

RESULTS: Thirteen eyes of 10 patients with retinoblastoma were included. MFI showed a prominent feeder vessel in 8 eyes, basket vasculature in 6 eyes and tumor bed vascularity in 10 eyes. MFI showed a more extensive vascular branching pattern that was not visible on color Doppler and fluorescein angiography in all eyes.

CONCLUSIONS: MFI of retinoblastoma patients could add information about tumor vascularity not detectable by color Doppler or fluorescein angiography. Further study is needed to determine whether this information could be used to predict prognosis for ocular salvage and tumor response to treatment.

Author List

Ramasubramanian A, Riemann M, Brown A, Abruzzo T, Goncalves LF

Author

Aparna Ramasubramanian MD Associate Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Fluorescein Angiography
Humans
Pilot Projects
Retinal Neoplasms
Retinoblastoma
Ultrasonography