A Case of Weak D Serologic Phenotype. WMJ 2024 Feb;123(1):56-58
Date
03/04/2024Pubmed ID
38436642Scopus ID
2-s2.0-85186568156 (requires institutional sign-in at Scopus site)Abstract
INTRODUCTION: Rh D alloimmunization is the serologic response that occurs when Rh D-negative patients are exposed to Rh D-positive blood. Rh D blood typing is recommended in pregnancy to prevent alloimmunization.
CASE PRESENTATION: A 27-year-old gravida 3, para 2012 (G3P2012) previously Rh D-negative female presented with discordant and weakly positive Rh D blood typing results. Confirmatory genetic testing revealed weak D phenotype that can be treated clinically as Rh D-positive.
DISCUSSION: Genetic variants of Rh D can cause varied blood typing results depending on the hospital reporting protocol utilized. If labeled as Rh D-negative, this could lead to unnecessary administration of Rh D immunoglobulin in pregnancy. Genetic variants should be suspected when patients are noted to have blood typing results that are discordant or weakly positive.
CONCLUSIONS: Rh D genotyping should be considered when discordant or weakly positive Rh D blood type results are noted in order to confirm and classify genetic subtype.
Author List
Boshoven AM, Verhagen LAuthor
Alice Boshoven MD Assistant Professor in the Family Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultFemale
Genetic Testing
Gravidity
Humans
Phenotype
Pregnancy