Faculty Collaboration Database

Spatial correspondence of cortical activity measured with whole head fNIRS and fMRI: Toward clinical use within subject. Neuroimage 2024 Apr 15;290:120569

Date

03/11/2024

Pubmed ID

38461959

DOI

10.1016/j.neuroimage.2024.120569

Scopus ID

2-s2.0-85187990515 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

Functional near infrared spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI) both measure the hemodynamic response, and so both imaging modalities are expected to have a strong correspondence in regions of cortex adjacent to the scalp. To assess whether fNIRS can be used clinically in a manner similar to fMRI, 22 healthy adult participants underwent same-day fMRI and whole-head fNIRS testing while they performed separate motor (finger tapping) and visual (flashing checkerboard) tasks. Analyses were conducted within and across subjects for each imaging approach, and regions of significant task-related activity were compared on the cortical surface. The spatial correspondence between fNIRS and fMRI detection of task-related activity was good in terms of true positive rate, with fNIRS overlap of up to 68 % of the fMRI for analyses across subjects (group analysis) and an average overlap of up to 47.25 % for individual analyses within subject. At the group level, the positive predictive value of fNIRS was 51 % relative to fMRI. The positive predictive value for within subject analyses was lower (41.5 %), reflecting the presence of significant fNIRS activity in regions without significant fMRI activity. This could reflect task-correlated sources of physiologic noise and/or differences in the sensitivity of fNIRS and fMRI measures to changes in separate (vs. combined) measures of oxy and de-oxyhemoglobin. The results suggest whole-head fNIRS as a noninvasive imaging modality with promising clinical utility for the functional assessment of brain activity in superficial regions of cortex physically adjacent to the skull.

Author List

Zinos A, Wagner JC, Beardsley SA, Chen WL, Conant L, Malloy M, Heffernan J, Quirk B, Prost R, Maheshwari M, Sugar J, Whelan HT

Authors

Scott Beardsley PhD Associate Professor in the Biomedical Engineering department at Marquette University
Mohit Maheshwari MD Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Hemodynamics
Humans
Magnetic Resonance Imaging
Skull
Spectroscopy, Near-Infrared