Targeting mitochondrial dynamics and redox regulation in cardiovascular diseases. Trends Pharmacol Sci 2024 Apr;45(4):290-303
Date
03/09/2024Pubmed ID
38458847DOI
10.1016/j.tips.2024.02.001Scopus ID
2-s2.0-85187360123 (requires institutional sign-in at Scopus site)Abstract
Accumulating evidence highlights the pivotal role of mitochondria in cardiovascular diseases (CVDs). Understanding the molecular mechanisms underlying mitochondrial dysfunction is crucial for developing targeted therapeutics. Recent years have seen substantial advancements in unraveling mitochondrial regulatory pathways in both normal and pathological states and the development of potent drugs. However, specific delivery of drugs into the mitochondria is still a challenge. We present recent findings on regulators of mitochondrial dynamics and reactive oxygen species (ROS), critical factors influencing mitochondrial function in CVDs. We also discuss advancements in drug delivery strategies aimed at overcoming the technical barrier in targeting mitochondria for CVD treatment.
Author List
Beg MA, Huang M, Vick L, Rao KNS, Zhang J, Chen YAuthor
Yiliang Chen PhD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Cardiovascular DiseasesHumans
Mitochondria
Mitochondrial Dynamics
Oxidation-Reduction
Reactive Oxygen Species
