Faculty Collaboration Database

Side of seizure focus predicts left medial temporal lobe activation during verbal encoding. Neurology 1998 Aug;51(2):479-84

Date

08/26/1998

Pubmed ID

9710022

DOI

10.1212/wnl.51.2.479

Scopus ID

2-s2.0-0031752418 (requires institutional sign-in at Scopus site)   99 Citations

Abstract

OBJECTIVE: Functional MRI (FMRI) was used to investigate the effect of medial temporal lobe (MTL) pathology on activation of language encoding areas in patients with temporal lobe epilepsy (TLE).

METHODS: Whole-brain FMRI was obtained. Twenty-eight patients with either left TLE (LTLE) or right TLE (RTLE) performed a semantic decision task alternating with an auditory perceptual task.

RESULTS: Activation of language areas in the frontal and parietal lobes was similar in both groups, with no group differences in the total number of active voxels. However, the RTLE group showed much stronger activation of the left MTL, including the hippocampus, parahippocampal gyrus, and collateral sulcus, than did the LTLE group.

CONCLUSIONS: Activation of the left MTL during semantic encoding discriminates patients with RTLE and LTLE. This FMRI technique may potentially be of use in determining memory lateralization and for predicting the side of seizure focus in TLE.

Author List

Bellgowan PS, Binder JR, Swanson SJ, Hammeke TA, Springer JA, Frost JA, Mueller WM, Morris GL

Authors

Jeffrey R. Binder MD Professor in the Neurology department at Medical College of Wisconsin
Wade M. Mueller MD Professor in the Neurosurgery department at Medical College of Wisconsin
Sara J. Swanson PhD Chief, Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Brain Mapping
Epilepsy, Temporal Lobe
Female
Functional Laterality
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Temporal Lobe
Verbal Learning