Faculty Collaboration Database

The associations of body size and body composition with left ventricular mass: impacts for indexation in adults. J Am Coll Cardiol 1998 Aug;32(2):451-7

Date

08/26/1998

Pubmed ID

9708475

DOI

10.1016/s0735-1097(98)00240-x

Scopus ID

2-s2.0-0032145715 (requires institutional sign-in at Scopus site)   132 Citations

Abstract

OBJECTIVES: We investigated the relationship between body size, body composition and left ventricular mass (LVM) in adults, and assessed the impact of different indexations of LVM on its associations with gender, adiposity and blood pressure.

BACKGROUND: The best way to normalize LVM for body size to appropriately distinguish physiologic adaptation from morbid heart morphology was discussed.

METHODS: We undertook a community survey of 653 men and 718 women, aged 25 to 74 years. Lean body mass (LBM) was determined by bioelectric impedance analyses and LVM was assessed by two-dimensional guided M-mode echocardiography.

RESULTS: After traditional indexations to body height, body height2.7, or body surface area, men had higher LVM than women (p < 0.001). These gender differences disappeared (p > 0.05) when LVM was indexed to LBM. The type of indexation also modified the strength of the association between adiposity and LVM. The estimated impact of body fat on LVM indexed to LBM was less than half that obtained with traditional indexations. In contrast, the magnitude of the associations of blood pressure with LVM was entirely independent of the type of indexation.

CONCLUSIONS: This study showed the prominent influence of body composition on adult heart size. Indexation for LBM removed gender differences for LVM and reduced the impact of adiposity, but left the effects of blood pressure unchanged. We suggest that this approach be used for clinical and research applications.

Author List

Hense HW, Gneiting B, Muscholl M, Broeckel U, Kuch B, Doering A, Riegger GA, Schunkert H

Author

Ulrich Broeckel MD Chief, Center Associate Director, Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adaptation, Physiological
Adipose Tissue
Adult
Aged
Blood Pressure
Body Composition
Body Constitution
Body Height
Body Mass Index
Body Surface Area
Body Weight
Echocardiography
Electric Impedance
Female
Heart
Heart Diseases
Heart Ventricles
Humans
Male
Middle Aged
Muscle, Skeletal
Sex Factors