Kainic acid lesions enhance locomotor responses to novelty, saline, amphetamine, and MK-801. Behav Brain Res 1997 Mar;84(1-2):47-55
Date
03/01/1997Pubmed ID
9079771DOI
10.1016/s0166-4328(96)00132-5Scopus ID
2-s2.0-0031047497 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
Intracerebroventricular (i.c.v.) administration of kainic acid (KA) to rats produces neuronal loss in the hippocampus and other areas of the limbic system. The present study demonstrates that i.c.v. KA enhances the locomotor response to novelty and saline injection, as well as to amphetamine and MK-801. Sixteen to 18 days after i.c.v. administration of KA or vehicle, lesioned and control rats were placed in a novel cage, and locomotor activity and grooming were recorded for 30 min prior to and 60 min following a subcutaneous injection of saline, D-amphetamine, or MK-801. In response to the novel cage and after each injection, KA rats exhibited increased locomotor activity relative to controls. Grooming behavior was found to be elevated in the KA rats when compared to controls, but only in response to the novel cage and saline injection. The possibility that damage to the limbic system disrupts dopaminergic regulation of locomotor behavior is discussed, as well as implications for neuropathology in schizophrenia.
Author List
Bardgett ME, Jacobs PS, Jackson JL, Csernansky JGAuthor
Jeffrey L. Jackson MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDextroamphetamine
Dizocilpine Maleate
Dopamine Uptake Inhibitors
Environment
Excitatory Amino Acid Agonists
Excitatory Amino Acid Antagonists
Grooming
Hippocampus
Injections, Intraventricular
Kainic Acid
Male
Motor Activity
Rats
Rats, Sprague-Dawley
