Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis. Arthritis Rheum 2004 Feb 15;51(1):9-13
Date
02/12/2004Pubmed ID
14872449DOI
10.1002/art.20076Scopus ID
2-s2.0-1242269398 (requires institutional sign-in at Scopus site) 204 CitationsAbstract
OBJECTIVE: To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia.
METHODS: Articles describing randomized, placebo-controlled trials of cyclobenzaprine in people with fibromyalgia were obtained from Medline, EMBase, Psyclit, the Cochrane Library, and Federal Research in Progress Database. Unpublished literature and bibliographies were also reviewed. Outcomes, including global improvement, treatment effects on pain, fatigue, sleep, and tender points over time, were abstracted.
RESULTS: Five randomized, placebo-controlled trials were identified. The odds ratio for global improvement with therapy was 3.0 (95% confidence interval [95% CI] 1.6-5.6) with a pooled risk difference of 0.21 (95% CI 0.09-0.34), which calculates to 4.8 (95% CI 3.0-11) individuals needing treatment for 1 patient to experience symptom improvement. Pain improved early on, but there was no improvement in fatigue or tender points at any time.
CONCLUSION: Cyclobenzaprine-treated patients were 3 times as likely to report overall improvement and to report moderate reductions in individual symptoms, particularly sleep.
Author List
Tofferi JK, Jackson JL, O'Malley PGAuthor
Jeffrey L. Jackson MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AmitriptylineDatabases, Factual
Fatigue
Female
Fibromyalgia
Humans
Male
Middle Aged
Muscle Relaxants, Central
Pain
Placebos
Randomized Controlled Trials as Topic
Treatment Outcome
