Faculty Collaboration Database

Central oxytocin attenuates augmented gastric postprandial motility induced by restraint stress in rats. Neurosci Lett 2010 Aug 02;479(3):302-6

Date

07/20/2010

Pubmed ID

20639005

DOI

10.1016/j.neulet.2010.05.085

Scopus ID

2-s2.0-77954145247 (requires institutional sign-in at Scopus site)   30 Citations

Abstract

Restraint stress delays gastric emptying via uncoordinated motility pattern in rats. Central oxytocin has anxiolytic effects and attenuates the hypothalamic-pituitary-adrenal (HPA) axis in response to stress and facilitates stress-induced delayed gastric emptying. However, the role of central oxytocin in regulating gastric motility remains unknown. Postprandial gastric motility was recorded via a strain-gauge transducer, implanted on the antrum in Sprague-Dawley (SD) rats. To investigate whether central and peripheral oxytocin are involved in gastric motility, oxytocin (10 microg) was administered intracerebroventricularly (icv) and intraperitoneally (ip). Central and peripheral oxytocin administration did not affect the postprandial gastric motility under non-stressed conditions. Restraint stress augmented gastric contractions. Central administration of oxytocin, but not peripheral administration, abolished the augmented postprandial gastric contractions induced by restraint stress. Oxytocin facilitates stress-induced delayed gastric emptying via alleviating uncoordinated gastric motility. Oxytocin might be a candidate for the treatment of stress-induced GI motility disorders.

Author List

Bülbül M, Babygirija R, Ludwig K, Takahashi T

Author

Kirk A. Ludwig MD Chief, Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Gastrointestinal Motility
Injections, Intraperitoneal
Injections, Intraventricular
Male
Muscle Contraction
Muscle, Smooth
Oxytocin
Postprandial Period
Rats
Rats, Sprague-Dawley
Restraint, Physical
Stomach
Stress, Psychological