Faculty Collaboration Database

Modeling withdrawal syndrome in zebrafish. Behav Brain Res 2010 Apr 02;208(2):371-6

Date

12/17/2009

Pubmed ID

20006651

DOI

10.1016/j.bbr.2009.12.004

Scopus ID

2-s2.0-77249092444 (requires institutional sign-in at Scopus site)   153 Citations

Abstract

The zebrafish (Danio rerio) is rapidly becoming a popular model species in behavioral neuroscience research. Zebrafish behavior is robustly affected by environmental and pharmacological manipulations, and can be examined using exploration-based paradigms, paralleled by analysis of endocrine (cortisol) stress responses. Discontinuation of various psychotropic drugs evokes withdrawal in both humans and rodents, characterized by increased anxiety. Sensitivity of zebrafish to drugs of abuse has been recently reported in the literature. Here we examine the effects of ethanol, diazepam, morphine and caffeine withdrawal on zebrafish behavior. Overall, discontinuation of ethanol, diazepam and morphine produced anxiogenic-like behavioral or endocrine responses, demonstrating the utility of zebrafish in translational research of withdrawal syndrome.

Author List

Cachat J, Canavello P, Elegante M, Bartels B, Hart P, Bergner C, Egan R, Duncan A, Tien D, Chung A, Wong K, Goodspeed J, Tan J, Grimes C, Elkhayat S, Suciu C, Rosenberg M, Chung KM, Kadri F, Roy S, Gaikwad S, Stewart A, Zapolsky I, Gilder T, Mohnot S, Beeson E, Amri H, Zukowska Z, Soignier RD, Kalueff AV

Author

Carisa Bergner Biostatistician II in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Anxiety
Behavior, Animal
Caffeine
Diazepam
Disease Models, Animal
Ethanol
Exploratory Behavior
Female
Hydrocortisone
Male
Morphine
Substance Withdrawal Syndrome
Time Factors
Zebrafish