Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Functional MR of frontal lobe activation: comparison with Wada language results. AJNR Am J Neuroradiol 1998;19(6):1095-8

Date

07/22/1998

Pubmed ID

9672017

Pubmed Central ID

PMC8338662

Scopus ID

2-s2.0-0032471920 (requires institutional sign-in at Scopus site)   161 Citations

Abstract

PURPOSE: Our purpose was to determine the utility of functional MR imaging in conjunction with a word-generation paradigm in the assessment of language lateralization.

METHODS: Functional MR imaging and Wada testing for language lateralization was performed in patients with complex partial seizures during the performance of word-generation tasks. A language lateralization quotient was calculated from the number of activated pixels in the right and left hemispheres. A language laterality score was derived from the Wada results as the percentage of correct responses during right internal carotid artery injection minus the percentage of correct responses during left internal carotid injection. A correlation coefficient between the functional MR imaging results and the Wada language laterality scores was calculated.

RESULTS: In 13 patients, hemispheric dominance based on Wada testing was confirmed by functional MR imaging during silent word generation. The Wada laterality scores varied from 100 to -100 and the functional MR imaging scores varied from 100 to -10. The language lateralization scores determined by functional MR imaging correlated significantly with the language lateralization scores derived from Wada testing.

CONCLUSION: Functional MR imaging performed during word generation is an accurate method for lateralizing language function in patients with complex partial epilepsy.

Author List

Yetkin FZ, Swanson S, Fischer M, Akansel G, Morris G, Mueller W, Haughton V

Authors

Wade M. Mueller MD Professor in the Neurosurgery department at Medical College of Wisconsin
Sara J. Swanson PhD Chief, Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Arousal
Brain Mapping
Dominance, Cerebral
Epilepsy
Female
Frontal Lobe
Humans
Language Tests
Magnetic Resonance Imaging
Male
Mental Recall
Verbal Behavior