[HYDROGEN SULFIDE DONOR, NAHS, RECOVERS CONSTITUTIVE NO SYNTHESIS AND ENDOTHELIUM-DEPENDENT RELAXATION OF ISOLATED AORTA IN OLD RATS]. Fiziol Zh (1994) 2015;61(6):3-10
Date
01/01/2015Pubmed ID
27025039DOI
10.15407/fz61.06.003Scopus ID
2-s2.0-84988836331 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
The objective of this study was to show the effect of H₂S donor, NaHS on the endothelium-dependent vasorelaxation, free radical state and cNOS uncoupling in old rats. In the aorta of old rats a combined oxidative and nitrosative stress develops that leads to cNOS uncoupling and decreased constitutive synthesis of the NO. That biochemical changes correlate with lowering of the endothelium-dependent relaxation of aortic smooth muscles (7.5 ± 1.4%, compared with 64.9 ± 3.5% in adults). It was found that, due to the combined inhibition of oxidative and nitrosative stress, NaHS restores constitutive de novo synthesis of NO by restoring cNOS coupling. Additionally, NaHS improves endothelium-dependent vasorelaxation by increasing (by 6.5 times) Ach-induced relaxation of aortic smooth muscles.
Author List
Drachuk KO, Kotsjuruba AV, Sagach VFAuthor
Kostiantyn Drachuk Postdoctoral Fellow in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgingAnimals
Aorta
Free Radicals
Gene Expression
Hydrogen Sulfide
Male
Muscle, Smooth, Vascular
Nitric Oxide
Nitric Oxide Synthase Type III
Rats
Rats, Wistar
Sulfides
Vasodilation
Vasodilator Agents
